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Avodart dutasteride dosage range, which has the following potential side effects: constipation (0.5 mg per day), dry mouth (1000 mg twice daily), dry skin (500 mg twice daily), and nausea (2000 mg twice daily) for 1-6 months. One potential adverse effect of dutasteride is gynecomastia. The pharmacology of dutasteride is as follows: acts at the 5-HT 2B, 3, 6, and 7 receptors (Karpova et al. 2010). In the dorsal raphé nucleus, dutasteride binds to the 5-HT 2B receptor and inhibits DAT activity (Nair et al. 1999). The 5-HT 3 receptor, on other hand, is the most abundant receptor in peripheral blood, and dutasteride is known to activate it in brain and spinal cord neurons (Davila et al. 2005; Sivier 2013; Wong et al. Wong, 2014). The 5-HT 6 and 7 receptors are localized to most cell types of the central nervous system (Yang et al. 2002). Pharmacological studies have demonstrated that 5-HT receptors are important in the regulation and of mood memory, although no serotonin-receptor antagonist has been approved by the FDA. However, these agents, particularly 5-HT 1a and 1b -agonists, do have the potential to cause adverse effects and are of utmost importance in the study of central nervous system (CNS) disorders. Recent data suggest that a 5a-adrenoceptoreceptor antagonist may have different effects on cognitive function depending the type of 5a receptor that it interacts with. In rodents, the 5-HT 1b (Agonist D1 receptor) antagonist N-NAPRTIL attenuates stress-induced cognitive impairment and improves memory anxiety-like behavior (Saggea et al. 1999).
Dutasteride is a potent and selective 5a-adrenoceptor antagonist, blocking both the 5a- and 5b-receptor (Sakaguchi et al. 2006; Höhn 2009). Additionally, one of the main side effects is gynecomastia, which the most common drug-induced clitoromegaly. 5-HT 7 receptor antagonist nifedipine was recently shown to be effective in treating gynecomastia patients with hypothalamic amenorrhea treated on contraceptives (Wong et al. 2013). Furthermore, 5a-adrenoceptor blockade has been shown to have strong beneficial effects in preventing cardiovascular disease, such as endothelial dysfunction and myocardial infarction (Huang et al. 1998).
In the present study, we used dutasteride hydrochloride (100 mg daily) and dutasteride (200 twice combination tablets to treat gynecomastia and test for the effect of selective 5a-adrenoceptor antagonist. The aim of study was to determine the efficacy of these two dutasteride regimens. Moreover, in order to confirm the clinical significance of drug action, it was considered necessary to characterize the side effects related to gynecomastia and)
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