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Cymbalta dosage 40 mg /d for up to 6 months with or without concomitant medications (e.g., anticonvulsants, mood stabilizers, or antipsychotics) and to assess safety; • assess the pharmacodynamics and safety tolerability of mirtazapine (10 mg/d for up to 6 months with or without concomitant medications) and of lurasidone (80 mg/d for up to 6 months with or without concomitant medications); • assess the pharmacodynamics and safety of nifedipine (20–80 mg/d for up to 12 weeks with concomitant antipsychotic medication) and of risperidone (60–120 mg/d for up to 12 weeks with concomitant antipsychotic medication) and assess the effects on quality of life; • evaluate the pharmacodynamic and safety tolerability of buspirone (200 mg/d for at least 12 weeks with concomitant antipsychotic medication) and of nefazodone (200 mg/d for at least 12 weeks with concomitant antipsychotic medication) and assess the effects on quality of life; and • evaluate the safety and pharmacodynamics of risperidone (600 mg/d for at least 12 weeks with concomitant antipsychotic medication) and of sertindole (150 mg/d for at least 12 weeks with concomitant antipsychotic medication) and assess the effects on quality of life. Patients will be assessed at the 2- and 12-month visits their clinical progress assessed at the 6-month visit. visit should include the assessment of a second set scales to assess the efficacy and safety of treatments. 6. Discussion This is a single-center, uncontrolled, multicenter, randomized clinical trial in healthy adults who have previously been diagnosed with schizophrenia, who have either had a relapse (see Figure 1) or who have had a full course of antipsychotic medication and have a GAF score of 20–30. The participants will not be receiving other care or treatment. Exclusion Criteria Adults who are taking other medications including AEDs and who are taking other concomitant drugs such as antihistamines, sedatives, or stimulants. Adults who have had a history of psychosis or who have a positive urine toxicology screen for other drugs. Intervention The study team will introduce a drug and monitor the patient through a 4- to 6-week treatment course assess efficacy and safety. Patients will be randomly assigned to receive 1 of 4 study-drug regimens: • Adjunctive medication with Mirtazapine 40 mg/d or 10 for 6–12 months with or without concomitant antipsychotic medications (e.g., nifedipine, risperidone, or buspirone); • Adjunctive medication with Mirtazapine 40 mg/d or 10 for 12–24 months with or without concomitant antipsychotic medications (e.g., nifedipine, risperidone, or buspirone); • Adjunctive medication with Mirtazapine 40 mg/d or 10 for up to 6 months with or without concomitant medications (e.g., antipsychotics, mood stabilizers, and antipsychotics with or without concomitant mood stabilizers); • Adjunctive medication with Mirtazapine 40 mg/d or 10 for up to 12 months with or without concomitant medications (e.g., antipsychotics, mood stabilizers, and antipsychotics with or without concomitant mood stabilizers); and will assess safety at each 6-month visit. the 12-month visit, a subgroup of patients will receive lurasidone (80 mg/d), and a cymbalta dosage 40 mg subgroup will receive buspirone (60–120 mg/d). Patients will continue to receive study drug, and the same personnel will continue to monitor them. The primary outcome of this trial will be a rate of change in the Positive and Negative Syndrome Scale (PANSS) total score from baseline to study conclusion. Safety of the study drugs will be monitored at the Cymbalta 180 Pills 30mg $459 - $2.55 Per pill 2- and 12-month visits at the 6-month visit. Schedules and Procedure The study will be conducted at 8 centers in the United States (see Figure 3) over a 12-month period. 1. Selection of Patients Patients with a diagnosis of schizophrenia who are eligible for study participation will be identified through a computer-generated random-digit dialing system.

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